Balancing supramolecular reagents for reliable formation of co-crystals.
نویسندگان
چکیده
The rational design and synthesis of a supramolecular reagent (SR) composed of two distinct hydrogen bonding sites (pyrazole-benzamide), and four co-crystals resulting from reactions between this SR and a variety of carboxylic acids are described; the observed primary intermolecular interaction is consistent and predictable in each case.
منابع مشابه
polymorphs, solvates and co-crystals. Functional groups that are self-complementary are capable of forming either a supramolecular homosynthons (eg-acid-acid and amide-amide homodimers or a supramolecular heterosynthon (carboxylicacid-amide heterodimers)
The emerging role of supramolecular chemistry and crystal engineering in pharmaceutical science has been influenced significantly by the interest in pharmaceutical cocrystals. Pharmaceutical co-crystals are co-crystals that are formed between an API (active pharmaceutical ingredient) and a co-crystal former that is a solid under ambient conditions. APIs contain functional groups that engage in ...
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ورودعنوان ژورنال:
- Chemical communications
دوره 13 شماره
صفحات -
تاریخ انتشار 2006